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작성일 : 18-08-01 09:23
Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis.
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis.
제 1저자, 교신저자: 김호연
나머지 저자: Kim HY, Kim WU, Cho ML, Lee SK, Youn JH, Kim SI, Yoo WH, Park JH, Min JK, Lee SH, Park SH, Cho CS.
학술지명: Arthritis and Rheumatism.
Vol(No),페이지:
발행년월일: 1999/10/01
v파일다운로드: 1999/10/01

Abstract

OBJECTIVE:

To determine the presence of specific immune recognition of type II collagen (CII) and its immunodominant epitope CII (255-274) in patients with rheumatoid arthritis (RA).

METHODS:

T cell proliferative responses to bovine CII and a synthetic peptide encompassing CII (255-274) in peripheral blood mononuclear cells (PBMC) and synovial fluid mononuclear cells (SFMC) from RA patients, and in PBMC from osteoarthritis (OA) patients and healthy controls were assayed by mixed lymphocyte culture.

RESULTS:

The stimulation index (SI) and the number of positive (SI > or = 2) T cell responses to CII were higher in RA patients (n = 106) than in OA patients (n = 26) and healthy controls (n = 34). T cell responses to CII (255-274) were also enhanced in RA patients and correlated well with those to CII. In SFMC, positive responses to CII or CII (255-274) were detected in 61.9% of 42 RA patients. T cell responses to CII in SFMC were stronger and more prevalent than peripheral responses. The SI and positive responses to CII were higher in early RA than in late RA. Levels of IgG antibodies to CII in synovial fluid inversely correlated with T cell responses to CII.

CONCLUSION:

T cell responses to CII or CII (255-274) were enhanced in RA, especially in early disease. Synthetic peptide CII (255-274), as well as native CII, could be recognized as immunogenic antigens by T cells, particularly in the synovial fluid. These observations suggest that CII-reactive T cells play an important role in the pathogenesis of RA. Peripheral tolerance induction using CII (255-274) might be useful in the treatment of RA.


 
 

 
Total 180
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황수연, Cho ML, Kim JY, Ko HJ, Kim YH, Kim WU, Cho CS, Kim HY, Hwang SY.
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Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts.
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김호연, Cho ML, Yoon CH, Hwang SY, Park MK, Min SY, Lee SH, Park SH, Kim HY.
Effector function of type II collagen-stimulated T cells from rheumatoid arthritis patients: cross-talk between T cells and synovial fibroblasts.
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Prostaglandin E2 suppresses nuclear factor-kappaB mediated interleukin 15 production in rheumatoid synoviocytes.
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김호연, Cho ML, Kim WU, Min SY, Min DJ, Min JK, Lee SH, Park SH, Cho CS, Kim HY.
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김호연, Min DJ, Cho ML, Cho CS, Min SY, Kim WU, Yang SY, Min JK, Hong YS, Lee SH, Park SH, Kim HY.
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김호연, Park SH, Min DJ, Cho ML, Kim WU, Youn J, Park W, Cho CS, Kim HY.
Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis.
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김호연, Kim WU, Min SY, Cho ML, Youn J, Min DJ, Lee SH, Park SH, Cho CS, Kim HY.
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김호연, Kim HY, Kim WU, Cho ML, Lee SK, Youn JH, Kim SI, Yoo WH, Park JH, Min JK, Lee SH, Park SH, Cho CS.
Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis.
Arthritis and Rheumatism., 1999/10/01,
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, Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
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, Moon SJ, Kim EK, Jhun JY, Lee HJ, Lee WS, Park SH, Cho ML, Min JK.
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, Lee SY, Min HK, Lee SH, Kwok SK, Ju JH, Cho ML, Park SH.
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