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작성일 : 18-08-01 09:32
The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis.
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis.
제 1저자, 교신저자: 김호연
나머지 저자: Kim WU, Min SY, Cho ML, Youn J, Min DJ, Lee SH, Park SH, Cho CS, Kim HY.
학술지명: Clinical and Experimental Immunology.
Vol(No),페이지:
발행년월일: 2000/01/01
v파일다운로드: 2000/01/01

Abstract

The aim of this study was to investigate the role of IL-12 in patients with RA. IL-12 (p70) and its associated cytokines were measured in sera and synovial fluid (SF) using an enzyme-linked immunosorbent method. Seven American College of Rheumatology (ACR) core set measures as well as IL-12 levels were sequentially monitored at the commencement and 4 months after treatment with a low-dose steroid and disease-modifying anti-rheumatic drugs (DMARDs). In sera, 64 (42.2%) of 152 RA patients had detectable concentrations of IL-12 (p70), whereas one (1.4%) of 69 osteoarthritis (OA) patients and five (10%) of 50 healthy controls had detectable IL-12 (P < 0.001). The median level of circulating IL-12 was also higher in RA patients (P < 0.001). In SF, the number of patients with detectable IL-12 and the median IL-12 levels were significantly higher in RA patients (n = 53) than in OA patients (n = 22). In paired samples (n = 53) of sera and SF from RA patients, IL-12 levels were higher in the SF than in sera (P < 0.001). Patients with detectable IL-12 (n = 51) in sera had higher tender joint scores (P = 0.003), swollen joint scores (P < 0.001) and C-reactive protein (CRP; P = 0.036), than those without (n = 55). Four months after treatment with DMARDs, the improved group showed a larger IL-12 decrease than the non-improved group (P = 0.017). The levels of IL-12 correlated positively with those of IL-2, interferon-gamma, IL-6, and tumour necrosis factor-alpha, but were correlated inversely with those of IL-10. Our results demonstrate that IL-12 levels reflect RA disease activity and that IL-12 is involved in the production of proinflammatory cytokines. An IL-12 blockade could be useful for the treatment of RA.


맛있다1 19-05-11 13:59
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맛있는건데… 19-05-30 15:01
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공기청정수기렌탈N,WOWT,WU,WV,WW,WX,WY,WZ추천
삼공기
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수원피부과수원피부과수원피부과
,WP,WQ,WR,WS,공기청정수기렌탈N,WOWT,WU,WV,WW,WX,WY,WZ추천
삼공기청정기추천
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https://www.google.com/
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https://m.daum.net/

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맛있는건데… 19-05-31 02:19
답변 삭제  
공기청정수기렌탈N,WOWT,WU,WV,WW,WX,WY,WZ추천
삼공기WM,WN,WOWT,WU,WV,WW,WX,WY,WZ추천
수원피부과수원피부과수원피부과수원피부과
,WP,WQ,WR,WS,공기청정수기렌탈N,WOWT,WU,WV,WW,WX,WY,WZ추천
삼공기청정기추천
,WP,WQ,WR,WS,공기청정수기렌탈
https://www.google.com/
https://m.naver.com/
https://m.daum.net/

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맛있는건데… 19-06-04 09:25
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공기청정렌탈,WW,WZ공기청공기청정WZ공기청공기청정수W,WZ공기청공기청정수W,WZ공기청공기청정수청기청공기청정OW,WZ공기청공기청정OW,WZ공기청공기청기청공기청정
렌탈N,WOW,WZ공기청공기청정수
수기렌탈,WZ추청정수기렌탈,WZ
https://www.google.com/
https://m.naver.com/
https://m.daum.net/

<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기">LG정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기렌탈">LG정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="엘지정수기">엘지정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="엘지정수기렌탈">엘지정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="공기청정기렌탈">공기청정기렌탈 </a>
<a href="https://www.lgeventmall.net/" target="_blank"title="정수기렌탈">정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="LG퓨리케어정수기">LG퓨리케어정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="안마의자렌탈">안마의자렌탈</a>
</table>

 
 

 
Total 180
국외
황수연, Cho ML, Kim JY, Ko HJ, Kim YH, Kim WU, Cho CS, Kim HY, Hwang SY.
The MCP-1 promoter -2518 polymorphism in Behcet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients.
Autoimmunity., 2004/02/01,
국외
김호연, Min DJ, Cho ML, Lee SH, Min SY, Kim WU, Min JK, Park SH, Cho CS, Kim HY.
Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts.
Arthritis and Rheumatism., 2004/04/01,
국외
김호연, Cho ML, Yoon CH, Hwang SY, Park MK, Min SY, Lee SH, Park SH, Kim HY.
Effector function of type II collagen-stimulated T cells from rheumatoid arthritis patients: cross-talk between T cells and synovial fibroblasts.
Arthritis and Rheumatism., 2004/03/01,
국외
김호연, Min SY, Kim WU, Cho ML, Hwang SY, Park SH, Cho CS, Kim JM, Kim HY.
Prostaglandin E2 suppresses nuclear factor-kappaB mediated interleukin 15 production in rheumatoid synoviocytes.
Journal of Rheumatology., 2002/07/01,
국외
조철수, Cho ML, Cho CS, Min SY, Kim SH, Lee SS, Kim WU, Min DJ, Min JK, Youn J, Hwang SY, Park SH, Kim HY.
Cyclosporine inhibition of vascular endothelial growth factor production in rheumatoid synovial fibroblasts.
Arthritis and Rheumatism., 2002/05/01,
국외
김호연, Cho ML, Kim WU, Min SY, Min DJ, Min JK, Lee SH, Park SH, Cho CS, Kim HY.
Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes.
Arthritis and Rheumatism., 2002/01/01,
국외 (1)
김호연, Min DJ, Cho ML, Cho CS, Min SY, Kim WU, Yang SY, Min JK, Hong YS, Lee SH, Park SH, Kim HY.
Decreased production of interleukin-12 and interferon-gamma is associated with renal involvement in systemic lupus erythematosus.
Scandinavian Journal of Rheumatology., 2001/05/01,
국외
김호연, Park SH, Min DJ, Cho ML, Kim WU, Youn J, Park W, Cho CS, Kim HY.
Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis.
Arthritis and Rheumatism., 2001/03/01,
국외
김호연, Cho CS, Cho ML, Min SY, Kim WU, Min DJ, Lee SS, Park SH, Choe J, Kim HY.
CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor.
Journal of Immunology., 2000/05/01,
국외 (4)
김호연, Kim WU, Min SY, Cho ML, Youn J, Min DJ, Lee SH, Park SH, Cho CS, Kim HY.
The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis.
Clinical and Experimental Immunology., 2000/01/01,
국외
김호연, Kim HY, Kim WU, Cho ML, Lee SK, Youn JH, Kim SI, Yoo WH, Park JH, Min JK, Lee SH, Park SH, Cho CS.
Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis.
Arthritis and Rheumatism., 1999/10/01,
국외
, Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
Fraxinellone Attenuates Rheumatoid Inflammation in Mice.
, ,
국외 (22)
, Moon SJ, Kim EK, Jhun JY, Lee HJ, Lee WS, Park SH, Cho ML, Min JK.
The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1.
Journal of Translational Medicine, ,
국외 (1)
, Lee SY, Min HK, Lee SH, Kwok SK, Ju JH, Cho ML, Park SH.
IL-1 receptor antagonist (IL-1Ra)-Fc ameliorate autoimmune arthritis by regulation of the Th17 cells/Treg balance and arthrogenic cytokine activation.
Immunology Letters, ,
국외 (4)
,
Supplementary materials (Halofuginone ameliorates autoimmune arthritis by regulating the balance between Th17 and regulatory T cells and inhibiting osteoclastogenesis)
, ,
 
 
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