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작성일 : 18-08-01 09:56
Decreased production of interleukin-12 and interferon-gamma is associated with renal involvement in systemic lupus erythematosus.
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: Decreased production of interleukin-12 and interferon-gamma is associated with renal involvement in systemic lupus erythematosus.
제 1저자, 교신저자: 김호연
나머지 저자: Min DJ, Cho ML, Cho CS, Min SY, Kim WU, Yang SY, Min JK, Hong YS, Lee SH, Park SH, Kim HY.
학술지명: Scandinavian Journal of Rheumatology.
Vol(No),페이지:
발행년월일: 2001/05/01
v파일다운로드: 2001/05/01

Abstract

OBJECTIVE:

To analyze the type 1/type 2 cytokine balance in patients with systemic lupus erythematosus (SLE) according to the presence of renal disorder and activity status.

METHODS:

We measured the serum levels of type 1 (IFN-gamma, IL-12) and type 2 cytokines (IL-4, IL-10) as well as spontaneous and stimulated cytokine production from peripheral blood mononuclear cells (PBMC) in 40 patients with SLE.

RESULTS:

Patients with lupus nephritis (LN) showed significantly lower levels of serum IL-12 and IFN-gamma than those without LN. Production of IL-12 and IFN-gamma by stimulated PBMC were also decreased in patients with LN. The circulating IL-12 correlated positively with IFN-gamma, but inversely with IL-10. The SLEDAI scores correlated well with the ratio of IL-4/IFN-gamma levels.

CONCLUSION:

The reduced production of IL-12 and IFN-gamma and the resultant shift towards the type 2 cytokine phenotype may be associated with LN.


맛있는건데… 19-06-04 09:25
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