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작성일 : 18-08-01 10:37
The MCP-1 promoter -2518 polymorphism in Behcet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients.
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: The MCP-1 promoter -2518 polymorphism in Behcet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients.
제 1저자, 교신저자: 황수연
나머지 저자: Cho ML, Kim JY, Ko HJ, Kim YH, Kim WU, Cho CS, Kim HY, Hwang SY.
학술지명: Autoimmunity.
Vol(No),페이지:
발행년월일: 2004/02/01
v파일다운로드: 2004/02/01

Abstract

OBJECTIVE:

To compare the G vs. A variation at the MCP-1 promoter -2518 position among normal Koreans and Behcet patients, and to investigate possible association of this polymorphism with disease pathogenesis.

METHODS:

The allele type of -2518 polymorphism was determined by restriction fragment length polymorphism of Pvu II. The level of MCP-1 in serum and culture supernatent was measured by sandwich ELISA.

RESULTS:

The average serum level of MCP-1 in Behcet patients was 2.37 times higher than in normal controls. The serum MCP-1 concentration was higher in G-allele carriers than in AA homozygotes, and symptoms accompanying graver cases of Behcet's disease, such as gastrointestinal inflammation and uveitis, were more frequent in patients with the G-allele. However, the frequency of G-allele in patient group was not higher than that in healthy Koreans, probably due to the dominance of G-allele in general Korean population. When stimulated in vitro with IL-1beta and LPS, the mononuclear cells from patients carrying the G-allele showed a steeper increase in MCP-1 production than the boost observed in AA homozygotes.

CONCLUSION:

Although the allele frequency of MCP-1 promoter -2518 polymorphism is not likely to be the reason for the elevated serum MCP-1 level in Korean patients with Behcet's disease, it is possible that proinflammatory factors induced in patients' serum cause stronger activation of MCP-1 expression from the G-type promoter, as well as increased incidence of uveitis and gastric ulcer, among carriers of the G-allele.


 
 

 
Total 180
국외
황수연, Cho ML, Kim JY, Ko HJ, Kim YH, Kim WU, Cho CS, Kim HY, Hwang SY.
The MCP-1 promoter -2518 polymorphism in Behcet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients.
Autoimmunity., 2004/02/01,
국외
김호연, Min DJ, Cho ML, Lee SH, Min SY, Kim WU, Min JK, Park SH, Cho CS, Kim HY.
Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts.
Arthritis and Rheumatism., 2004/04/01,
국외
김호연, Cho ML, Yoon CH, Hwang SY, Park MK, Min SY, Lee SH, Park SH, Kim HY.
Effector function of type II collagen-stimulated T cells from rheumatoid arthritis patients: cross-talk between T cells and synovial fibroblasts.
Arthritis and Rheumatism., 2004/03/01,
국외
김호연, Min SY, Kim WU, Cho ML, Hwang SY, Park SH, Cho CS, Kim JM, Kim HY.
Prostaglandin E2 suppresses nuclear factor-kappaB mediated interleukin 15 production in rheumatoid synoviocytes.
Journal of Rheumatology., 2002/07/01,
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조철수, Cho ML, Cho CS, Min SY, Kim SH, Lee SS, Kim WU, Min DJ, Min JK, Youn J, Hwang SY, Park SH, Kim HY.
Cyclosporine inhibition of vascular endothelial growth factor production in rheumatoid synovial fibroblasts.
Arthritis and Rheumatism., 2002/05/01,
국외
김호연, Cho ML, Kim WU, Min SY, Min DJ, Min JK, Lee SH, Park SH, Cho CS, Kim HY.
Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes.
Arthritis and Rheumatism., 2002/01/01,
국외 (1)
김호연, Min DJ, Cho ML, Cho CS, Min SY, Kim WU, Yang SY, Min JK, Hong YS, Lee SH, Park SH, Kim HY.
Decreased production of interleukin-12 and interferon-gamma is associated with renal involvement in systemic lupus erythematosus.
Scandinavian Journal of Rheumatology., 2001/05/01,
국외
김호연, Park SH, Min DJ, Cho ML, Kim WU, Youn J, Park W, Cho CS, Kim HY.
Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis.
Arthritis and Rheumatism., 2001/03/01,
국외
김호연, Cho CS, Cho ML, Min SY, Kim WU, Min DJ, Lee SS, Park SH, Choe J, Kim HY.
CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor.
Journal of Immunology., 2000/05/01,
국외 (4)
김호연, Kim WU, Min SY, Cho ML, Youn J, Min DJ, Lee SH, Park SH, Cho CS, Kim HY.
The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis.
Clinical and Experimental Immunology., 2000/01/01,
국외
김호연, Kim HY, Kim WU, Cho ML, Lee SK, Youn JH, Kim SI, Yoo WH, Park JH, Min JK, Lee SH, Park SH, Cho CS.
Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis.
Arthritis and Rheumatism., 1999/10/01,
국외
, Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
Fraxinellone Attenuates Rheumatoid Inflammation in Mice.
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, Moon SJ, Kim EK, Jhun JY, Lee HJ, Lee WS, Park SH, Cho ML, Min JK.
The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1.
Journal of Translational Medicine, ,
국외 (1)
, Lee SY, Min HK, Lee SH, Kwok SK, Ju JH, Cho ML, Park SH.
IL-1 receptor antagonist (IL-1Ra)-Fc ameliorate autoimmune arthritis by regulation of the Th17 cells/Treg balance and arthrogenic cytokine activation.
Immunology Letters, ,
국외 (4)
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Supplementary materials (Halofuginone ameliorates autoimmune arthritis by regulating the balance between Th17 and regulatory T cells and inhibiting osteoclastogenesis)
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