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작성일 : 18-08-10 13:55
IL-32 and IL-17 interact and have the potential to aggravate osteoclastogenesis in rheumatoid arthritis.
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: IL-32 and IL-17 interact and have the potential to aggravate osteoclastogenesis in rheumatoid arthritis.
제 1저자, 교신저자:
나머지 저자: Moon YM, Yoon BY, Her YM, Oh HJ, Lee JS, Kim KW, Lee SY, Woo YJ, Park KS, Park SH, Kim HY, Cho ML.
학술지명: ARTHRITIS RESEARCH & THERAPY
Vol(No),페이지:
발행년월일: 2012/11/13
v파일다운로드: 2012/11/13

Abstract

INTRODUCTION:

Interleukin (IL)-32 and IL-17 play critical roles in pro-inflammatory responses and are highly expressed in the synovium of patients with rheumatoid arthritis (RA). We investigated the relations between these two cytokines (IL-17 and IL-32) for their ability to induce each other and to stimulate osteoclasts in RA fibroblast-like synoviocytes (FLSs) and T cells.

METHODS:

FLSs were isolated through surgical synovectomy obtained from patients with RA or osteoarthritis (OA). Real-time PCR were performed to evaluate the expression of IL-32, IL-17 and osteoclast-related genes. Immunohistochemical staining and tartrate-resistant acid phosphatase (TRAP) staining were performed to determine the distribution of inflammatory cytokines and the presence of osteoclastogenesis.

RESULTS:

IL-17 induced the expression of IL-32 in the FLSs from RA patients, as assessed by microarray. IL-32 production was increased by IL-17. IL-32 in the FLSs from RA patients induced the production of IL-17 in CD4+ T cells. IL-32 and IL-17 were colocalized near TRAP-positive areas in joint specimens. IL-17 and IL-32 synergistically induced the differentiation of osteoclasts, as demonstrated by the expression of osteoclast-related genes. IL-32 and IL-17 also could induce resorption by osteoclasts in a RANKL-dependent manner.

CONCLUSIONS:

IL-17 affected the expression of IL-32 in FLSs of RA patients and IL-32 induced the production of IL-17 in CD4+ T cells. Both IL-17 and IL-32 cytokines can reciprocally influence each other's production and amplify the function of osteoclastogenesis in the in RA synovium. Separately, IL-17 and IL-32 each stimulated osteoclastogenesis without RANKL. Together, the two cytokines synergistically amplified the differentiation of osteoclasts, independent of RANKL stimulation.


맛있는건데… 19-06-02 07:50
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맛있는건데… 19-06-03 13:51
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맛있는건데… 19-06-06 05:27
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