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작성일 : 18-08-27 14:22
INTERFERON-GAMMA REGULATES INFLAMMATORY CELL DEATH BY TARGETING NECROPTOSIS IN EXPERIMENTAL AUTOIMMUNE ARTHRITIS
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: INTERFERON-GAMMA REGULATES INFLAMMATORY CELL DEATH BY TARGETING NECROPTOSIS IN EXPERIMENTAL AUTOIMMUNE ARTHRITIS
제 1저자, 교신저자:
나머지 저자: Lee SH, Kwon JY, Kim SY, Jung K, Cho ML.
학술지명: Scientific Reports
Vol(No),페이지:
발행년월일: 2017/08
v파일다운로드: 2017/08

Abstract

Interferon γ (IFN-γ) induces an inflammatory response and apoptotic cell death. Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with increased levels of inflammatory mediators, including tumour necrosis factor α (TNF-α) and T helper (Th) 17 cells, and downregulation of apoptosis of inflammatory cells. We hypothesized that IFN-γ would reduce inflammatory cell death in vitro and that loss of IFN-γ would aggravate inflammation in vivo. IFN-γ downregulated necroptosis and the expression of cellular FLICE-like inhibitory protein (cFLIPL) and mixed lineage kinase domain-like (MLKL). However, loss of IFN-γ promoted the production of cFLIPL and MLKL, and necroptosis. IFN-γ deficiency increased Th17 cell number and upregulated the expression of IL-17 and TNF-α. Expression of MLKL, receptor interacting protein kinase (RIPK)1, and RIPK3 was increased in the joints of mice with collagen-induced arthritis (CIA). Compared with wild-type mice with CIA, IFN-γ-/- CIA mice showed exacerbation of cartilage damage and joint inflammation, and acceleration of MLKL, RIPK1, and RIPK3 production in the joints. IFN-γ deficiency induced the activation of signal transducer and activator of transcript-xion 3. These results suggest that IFN-γ regulates inflammatory cell death and may have potential for use in the treatment of RA.


 
 

 
Total 180
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