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작성일 : 18-08-27 15:02
"The combination of probiotic complex, rosavin and zinc improves pain and cartilage destruction an in osteoarthritis rat model Short title: Probiotic complex, rosavin and zinc alleviates OA
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: "The combination of probiotic complex, rosavin and zinc improves pain and cartilage destruction an in osteoarthritis rat model Short title: Probiotic complex, rosavin and zinc alleviates OA
제 1저자, 교신저자:
나머지 저자: Kwon JY, Lee SH, Jhun J, Choi J, Jung K, Cho KH, Kim SJ, Yang CW, Park SH, Cho ML.
학술지명: Journal of Medicinal Food
Vol(No),페이지:
발행년월일: 2018/04/01
v파일다운로드: 2018/04/01

Osteoarthritis (OA), a degenerative disorder, induces pain, joint inflammation, and destruction of the articular cartilage matrix. Probiotic complex, rosavin, and zinc have been used as dietary supplements that exhibit anti-inflammatory and antioxidant properties. However, there is no evidence demonstrating a synergic effect in OA. This study aims to determine whether combination with probiotic complex, rosavin, and zinc decreases progression of monosodium iodoacetate (MIA)-induced OA rat model. The combination improved pain levels by preventing cartilage damage. The expression of proinflammatory cytokines and catabolic factors was reduced by the combination within the joint tissue. However, the combination increased anti-inflammatory cytokines as well as the anabolic factor production. The gene level of catabolic factors was decreased with treatment of the combination in chondrocytes isolated from OA patients. These results suggest that the combination can improve MIA development through the inhibition of proinflammatory cytokines and cartilage destruction, thus playing a key role as a therapeutic candidate for OA treatment.


 
 

 
Total 176
국외
, Park JS, Kim NR, Lim MA, Kim SM, Hwang SH, Jung KA, Choi J, Park SH, Cho ML.
Deficiency of IL-1 receptor antagonist suppresses IL-10-producing B cells in autoimmune arthritis in an IL-17/Th17-dependent manner To be published in: Immunology Letters
Immunology Letters, 2018/07,
국외
, Lee SH, Lee HR, Kwon JY, Jung K, Kim SY, Cho KH, Choi J, Lee HH, Lee BI, Jue DM, Cho ML.
A20 ameliorates inflammatory bowel disease in mice via inhibiting NF-κB and STAT3 activation.
Immunology Letters, 2018/06,
국외
, Jhun J, Lee SH, Lee SK, Kim HY, Jung ES, Kim DG, Choi J, Bae SH, Yoon SK, Chung BH, Yang CW, Cho ML, Choi JY.
Serial Monitoring of Immune Markers Being Represented Treg/Th17 Ratio: Indicating Tolerance for Tapering Immunosuppression after Liver Transplantation
Front Immunol., 2018/03,
국외
, Kwon JE, Lee SY, Seo HB, Moon YM, Ryu JG, Jung KA, Jhun JY, Park JS, Hwang SS, Kim JM, Lee GR, Park SH, Cho ML.
YinYang1 deficiency ameliorates joint inflammation in a murine model of rheumatoid arthritis by modulating Th17 cell activation.
Immunology Letters, 2018/05,
국외
, Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, Lee HJ, Kim EK, Jhun JY, Cho ML, Min JK, Cho YY.
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
Cell Death & Disease, 2018/03/01,
국외
, Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
Fraxinellone Attenuates Rheumatoid Inflammation in Mice.
International journal of molecular sciences, 2018/03/13,
국외
, Park MJ, Lee SH, Kim EK, Lee EJ, Baek JA, Park SH, Kwok SK, Cho ML.
Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice
Scientific Reports, 2018/02/01,
국외
, Park JS, Choi J, Kwon JY, Jung KA, Yang CW, Park SH, Cho ML.
A Probiotic Complex, Rosavin, Zinc, and Prebiotics Ameliorate Intestinal Inflammation in an Acute Colitis Mouse Model
"Journal of Translational Medicine, 2018/02/21,
국외
, Kim EK, Lee SH, Lee SY, Kim JK, Jhun JY, Na HS, Kim SY, Choi JY, Yang CW, Park SH, Cho ML.
Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation.
Experimental & Molecular Medicine, 2018/01/26,
국외
, Lee SY, Lee SH, Jhun J, Seo HB, Jung KA, Yang CW, Park SH, Cho ML.
A Combination with Probiotic Complex, Zinc, and Coenzyme Q10 Attenuates Autoimmune Arthritis by Regulation of Th17/Treg Balance.e
Journal of Medicinal Food, 2018/01,
국외
, Kwon JY, Lee SH, Jhun J, Choi J, Jung K, Cho KH, Kim SJ, Yang CW, Park SH, Cho ML.
"The combination of probiotic complex, rosavin and zinc improves pain and cartilage destruction an in osteoarthritis rat model Short title: Probiotic complex, rosavin and zinc alleviates OA
Journal of Medicinal Food, 2018/04/01,
국외
, Park JS, Choi J, Jhun J, Kwon JY, Lee BI, Yang CW, Park SH, Cho ML.
Lactobacillus acidophilus Improves Intestinal Inflammation in an Acute Colitis Mouse Model by Regulation of Th17 and Treg Cell Balance and Fibrosis Development.
Journal of Medicinal Food, 2018/03/01,
국외
, Moon YM, Lee SY, Kwok SK, Lee SH, Kim D, Kim WK, Her YM, Son HJ, Kim EK, Ryu JG, Seo HB, Kwon JE, Hwang SY, Youn J, Seong RH, Jue DM, Park SH, Kim HY, Ahn SM, Cho ML.
The Fos-Related Antigen 1– JUNB/ Activator Protein 1 Transcription Complex, a Downstream Target of Signal Transducer and Activator of Transcription 3, Induces T Helper 17 Differentiation and Promotes Experimental Autoimmune Arthritis
Front Immunol., 2017/12/18,
국외
, Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
Ethyl pyruvate ameliorates inflammatory arthritis in mice.
International Immunopharmacology, 2017/11,
국외
, Lee SH, Kwon JY, Kim SY, Jung K, Cho ML.
INTERFERON-GAMMA REGULATES INFLAMMATORY CELL DEATH BY TARGETING NECROPTOSIS IN EXPERIMENTAL AUTOIMMUNE ARTHRITIS
Scientific Reports, 2017/08,
 
 
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