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작성일 : 18-08-28 09:44
Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation.
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation.
제 1저자, 교신저자:
나머지 저자: Kim EK, Lee SH, Lee SY, Kim JK, Jhun JY, Na HS, Kim SY, Choi JY, Yang CW, Park SH, Cho ML.
학술지명: Experimental & Molecular Medicine
Vol(No),페이지:
발행년월일: 2018/01/26
v파일다운로드: 2018/01/26

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease involving excessive inflammation. Recently, RA associated with a metabolic disorder was revealed to be non-responsive to RA medications. Metformin has been reported to have a therapeutic effect on RA and obesity. The aim of this investigation was to study the therapeutic effect and the underlying mechanism of metformin's action in an experimental model of collagen-induced arthritis (CIA) associated with obesity. Metformin was administered daily for 13 weeks to mice with CIA that had been fed a high-fat diet. Metformin ameliorated the development of CIA in obese mice by reducing autoantibody expression and joint inflammation. Furthermore, metformin decreased the expression levels of pSTAT3 and pmTOR and had a small normalizing effect on the metabolic profile of obese CIA mice. In addition, metformin increased the production of pAMPK and FGF21. Metformin also induced the differentiation of brown adipose tissue (BAT), which led to a reciprocal balance between T helper (Th) 17 and regulatory T (Treg) cells in vitro and in vivo. These results suggest that metformin can dampen the development of CIA in obese mice and reduce metabolic dysfunction by inducing BAT differentiation. Thus, metformin could be a therapeutic candidate for non-responsive RA.


맛있다1 19-05-19 03:44
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dressing 19-10-19 10:10
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Jongno Restaurants Recommended for You! It's deliciously full ? How delicious ..
You've found a great restaurant! Deliciously full ? Beat your knees!
When I started dressing up, I got stuck.
It was the day I had without

spicyg 19-10-19 13:25
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It's quite wide. It has a light taste and it's spicy and more irritating.
It's unfamiliar because it
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cissorn 19-11-03 15:01
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I had scissors and tongs so I cut it easily
Eulwangri clam grilled restaurant recommended over! Delicious and ?
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