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작성일 : 18-08-28 10:39
Fraxinellone Attenuates Rheumatoid Inflammation in Mice.
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: Fraxinellone Attenuates Rheumatoid Inflammation in Mice.
제 1저자, 교신저자:
나머지 저자: Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
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Abstract

This study aimed to evaluate the therapeutic effect of fraxinellone on inflammatory arthritis and identify the underlying mechanisms. Fraxinellone (7.5 mg/kg) or a vehicle control was injected into mice with collagen-induced arthritis (CIA). The severity of arthritis was evaluated clinically and histologically. The differentiation of CD4⁺ T cells and CD19⁺ B cells was investigated in the presence of fraxinellone. Osteoclastogenesis after fraxinellone treatment was evaluated by staining with tartrate-resistant acid phosphatase (TRAP) and by measuring the mRNA levels of osteoclastogenesis-related genes. Fraxinellone attenuated the clinical and histologic features of inflammatory arthritis in CIA mice. Fraxinellone suppressed the production of interleukin-17 and the expression of RAR-related orphan receptor γ t and phospho-signal transducer and activator of transcript-xion 3 in CD4⁺ T cells. CD19⁺ B cells showed lower expression of activation-induced cytidine deaminase and B lymphocyte-induced maturation protein-1 after treatment with fraxinellone. The formation of TRAP-positive cells and the expression of osteoclastogenesis-related markers were reduced in the presence of fraxinellone. Inhibition of interleukin-17 and osteoclastogenesis was also observed in experiments using human peripheral mononuclear cells. Fraxinellone alleviated synovial inflammation and osteoclastogenesis in mice. The therapeutic effect of fraxinellone was associated with the inhibition of cellular differentiation and activation. The data suggests that fraxinellone could be a novel treatment for inflammatory arthritis, including rheumatoid arthritis.


 
 

 
Total 180
국외
황수연, Cho ML, Kim JY, Ko HJ, Kim YH, Kim WU, Cho CS, Kim HY, Hwang SY.
The MCP-1 promoter -2518 polymorphism in Behcet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients.
Autoimmunity., 2004/02/01,
국외
김호연, Min DJ, Cho ML, Lee SH, Min SY, Kim WU, Min JK, Park SH, Cho CS, Kim HY.
Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts.
Arthritis and Rheumatism., 2004/04/01,
국외
김호연, Cho ML, Yoon CH, Hwang SY, Park MK, Min SY, Lee SH, Park SH, Kim HY.
Effector function of type II collagen-stimulated T cells from rheumatoid arthritis patients: cross-talk between T cells and synovial fibroblasts.
Arthritis and Rheumatism., 2004/03/01,
국외
김호연, Min SY, Kim WU, Cho ML, Hwang SY, Park SH, Cho CS, Kim JM, Kim HY.
Prostaglandin E2 suppresses nuclear factor-kappaB mediated interleukin 15 production in rheumatoid synoviocytes.
Journal of Rheumatology., 2002/07/01,
국외
조철수, Cho ML, Cho CS, Min SY, Kim SH, Lee SS, Kim WU, Min DJ, Min JK, Youn J, Hwang SY, Park SH, Kim HY.
Cyclosporine inhibition of vascular endothelial growth factor production in rheumatoid synovial fibroblasts.
Arthritis and Rheumatism., 2002/05/01,
국외
김호연, Cho ML, Kim WU, Min SY, Min DJ, Min JK, Lee SH, Park SH, Cho CS, Kim HY.
Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes.
Arthritis and Rheumatism., 2002/01/01,
국외 (1)
김호연, Min DJ, Cho ML, Cho CS, Min SY, Kim WU, Yang SY, Min JK, Hong YS, Lee SH, Park SH, Kim HY.
Decreased production of interleukin-12 and interferon-gamma is associated with renal involvement in systemic lupus erythematosus.
Scandinavian Journal of Rheumatology., 2001/05/01,
국외
김호연, Park SH, Min DJ, Cho ML, Kim WU, Youn J, Park W, Cho CS, Kim HY.
Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis.
Arthritis and Rheumatism., 2001/03/01,
국외
김호연, Cho CS, Cho ML, Min SY, Kim WU, Min DJ, Lee SS, Park SH, Choe J, Kim HY.
CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor.
Journal of Immunology., 2000/05/01,
국외 (4)
김호연, Kim WU, Min SY, Cho ML, Youn J, Min DJ, Lee SH, Park SH, Cho CS, Kim HY.
The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis.
Clinical and Experimental Immunology., 2000/01/01,
국외
김호연, Kim HY, Kim WU, Cho ML, Lee SK, Youn JH, Kim SI, Yoo WH, Park JH, Min JK, Lee SH, Park SH, Cho CS.
Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis.
Arthritis and Rheumatism., 1999/10/01,
국외
, Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
Fraxinellone Attenuates Rheumatoid Inflammation in Mice.
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국외 (22)
, Moon SJ, Kim EK, Jhun JY, Lee HJ, Lee WS, Park SH, Cho ML, Min JK.
The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1.
Journal of Translational Medicine, ,
국외 (1)
, Lee SY, Min HK, Lee SH, Kwok SK, Ju JH, Cho ML, Park SH.
IL-1 receptor antagonist (IL-1Ra)-Fc ameliorate autoimmune arthritis by regulation of the Th17 cells/Treg balance and arthrogenic cytokine activation.
Immunology Letters, ,
국외 (4)
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Supplementary materials (Halofuginone ameliorates autoimmune arthritis by regulating the balance between Th17 and regulatory T cells and inhibiting osteoclastogenesis)
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