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작성일 : 18-08-28 14:03
A20 ameliorates inflammatory bowel disease in mice via inhibiting NF-κB and STAT3 activation.
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: A20 ameliorates inflammatory bowel disease in mice via inhibiting NF-κB and STAT3 activation.
제 1저자, 교신저자:
나머지 저자: Lee SH, Lee HR, Kwon JY, Jung K, Kim SY, Cho KH, Choi J, Lee HH, Lee BI, Jue DM, Cho ML.
학술지명: Immunology Letters
Vol(No),페이지:
발행년월일: 2018/06
v파일다운로드: 2018/06

Abstract

A20 is a zinc finger protein that effectively inhibits the activation of nuclear factor (NF)-κB to downregulate the expression of tumor necrosis factor-α, interleukin (IL)-1β, and IL-17. A20 also plays a crucial role as a feedback inhibitor of the inflammatory response. Due to its inhibitory role, A20 may be useful in regulating diseases resulting from chronic inflammation and excessive pro-inflammatory cytokine production, such as colitis. Patients with colitis produce high levels of pro-inflammatory cytokines in the intestine. Therefore, this study aimed to investigate whether A20 improves experimental colitis by reducing high levels of inflammation in the intestine. An A20 overexpression vector was administered to mice by intrarectal injection after colitis induction. Histological analysis by immunohistochemistry was used to score sections of the intestine. Confocal laser scanning microscopy was used to identify the expression of IL-17 and forkhead box p (FOXP) 3 protein in spleen tissues. Protein expression induced by STAT3 and NF-κB signaling was analyzed by western blot. We found that A20 reduced the colitis activity index score and the histological score of the intestine. A20 also decreased inflammatory cytokine levels in the intestine and increased colon length. Additionally, A20 overexpression downregulated the activation of NF-kB and STAT3. A20 also reduced IL-17 expression in CD4+ T cells from spleen sections. In contrast, A20 overexpression enhanced the expression of FOXP3 in CD4+ T cells. These results suggest that A20 may inhibit the progression of colitis by decreasing inflammation via inhibition of NF-κB, phosphorylated STAT3, and IL-17.


맛있는건데… 19-05-30 14:53
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맛있는건데… 19-05-30 15:02
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맛있는건데… 19-05-31 07:27
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맛있는건데… 19-06-01 05:14
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맛있는건데… 19-06-01 05:48
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맛있는건데… 19-06-02 06:39
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맛있는건데… 19-06-02 07:13
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맛있는건데… 19-06-02 10:02
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<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

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<a href="https://www.lgeventmall.net/" target="_blank"title="정수기렌탈">정수기렌탈</a>
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맛있는건데… 19-06-03 05:14
답변 삭제  
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https://www.google.com/
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<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

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<a href="https://www.lgeventmall.net/" target="_blank"title="정수기렌탈">정수기렌탈</a>
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<a href="https://www.lgeventmall.net/" target="_blank"title="안마의자렌탈">안마의자렌탈</a>
</table>

맛있는건데… 19-06-07 08:26
답변 삭제  
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https://www.google.com/
https://m.naver.com/
https://m.daum.net/

<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

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<a href="https://www.lgeventmall.net/" target="_blank"title="안마의자렌탈">안마의자렌탈</a>
</table>

맛있는건데… 19-06-07 08:40
답변 삭제  
공기청정렌탈,WW청청기청기청정수청공기청정
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https://www.google.com/
https://m.naver.com/
https://m.daum.net/

<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기">LG정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기렌탈">LG정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="엘지정수기">엘지정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="엘지정수기렌탈">엘지정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="공기청정기렌탈">공기청정기렌탈 </a>
<a href="https://www.lgeventmall.net/" target="_blank"title="정수기렌탈">정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="LG퓨리케어정수기">LG퓨리케어정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="안마의자렌탈">안마의자렌탈</a>
</table>

zkhxdsdol 19-06-08 02:55
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맛있는건데… 19-06-10 10:18
답변 삭제  
공기청정렌탈,WW청청기청기청정수청공기청정
렌탈N,WOW,WZ공기청공기청기청정수청공기청정
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https://www.google.com/
https://m.naver.com/
https://m.daum.net/

<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기">LG정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기렌탈">LG정수기렌탈</a>
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</table>

맛있는건데… 19-06-10 11:13
답변 삭제  
공기청정렌탈,WW청청기청기청정수청공기청정
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https://www.google.com/
https://m.naver.com/
https://m.daum.net/

<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

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<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기렌탈">LG정수기렌탈</a>
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<a href="https://www.lgeventmall.net/" target="_blank"title="엘지정수기렌탈">엘지정수기렌탈</a>
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</table>

맛있는건데… 19-06-11 04:07
답변 삭제  
공기청정렌탈,WW청청기청기청정수청공기청정
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https://m.daum.net/

<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
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맛있는건데… 19-06-11 04:56
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공기청정렌탈,WW청청기청기청정수청렌탈N,WOW,WZ공기청공기청기청정수청공기청정
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맛있는건데… 19-06-11 05:40
답변 삭제  
공기청정렌탈,WW청청기청기청정수청렌탈N,WOW,WZ공기청공기청기청정수청공기청정청정수청렌탈N,WOW,WZ공기청공기청기청정수청공기청정
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<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
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<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
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<a href="https://www.lgeventmall.net/" target="_blank"title="정수기렌탈">정수기렌탈</a>
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</table>

맛있는건데… 19-06-11 06:54
답변 삭제  
공기청정렌탈,WW청청기청기청정수청렌탈N,WOW,WZ공기청공기청기청정수청공기청정청정수청렌탈N,WOW청공기,WZ공기청공기청기청정수청공기청정
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https://www.google.com/
https://m.naver.com/
https://m.daum.net/

<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

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</table>

맛있는건데… 19-06-11 07:38
답변 삭제  
공기청정렌탈,WW청청기청기청정수청렌탈N,WOW,WZ공기청공기청기청정수청공기청정청정수청렌탈N,WOW청공기,WZ공기청공기청기청정수청공기청정
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렌탈N,WOW,WZ공기청공기청정
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https://www.google.com/
https://m.naver.com/
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<a href="https://m.naver.com/" target="_blank"title="네이버">네이버</a>
<a href="https://www.google.com/" target="_blank"title="구글">구글</a>
<a href="https://www.daum.net/" target="_blank"title="다음">다음</a>

<a href="https://m.blog.naver.com/sstt3324a/221498047001" target="_blank"title="강릉 맛집">강릉 맛집</a>
<a href="https://m.blog.naver.com/ansantigers/221400723052" target="_blank"title="건대 맛집">건대 맛집</a>
<a href="https://m.blog.naver.com/q931c4921/221419173236" target="_blank"title="송파구치과">송파구치과</a>

<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기">LG정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="LG정수기렌탈">LG정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="엘지정수기">엘지정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="엘지정수기렌탈">엘지정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="공기청정기렌탈">공기청정기렌탈 </a>
<a href="https://www.lgeventmall.net/" target="_blank"title="정수기렌탈">정수기렌탈</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="LG퓨리케어정수기">LG퓨리케어정수기</a>
<a href="https://www.lgeventmall.net/" target="_blank"title="안마의자렌탈">안마의자렌탈</a>
</table>

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Total 180
국외
Kyoung Woon Kim, Byung Ha Chung, Kim Bo-Mi Kim, Kyoung Chan Doh, Mi-La Cho, Chul Woo Yang,
Clinical significance of CCR7+CD8+ T cells in kidney transplant recipients
Scientific Reprots, 2018-06,
국외
Jin-Sil Park, Mi-La Cho, Sung-Hwan Park, Sung-Min Kim, Sun-Hee Hwang, Si-Young Choi, Ji Ye Kwon, Seung-Ki Kwok,
Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells
International Journal of Immunopathology and Pharmacology , 2018-06,
국외
Jung Min Bae, Han Hee Lee,Bo-In Lee,Kang-Moon Lee, Eun SH, Cho ML, Kim JS, Park JM, Cho YS, Lee IS, Kim SW, Choi H, Choi MG.
Incidence of psoriasiform diseases secondary to tumour necrosis factor antagonists in patients with inflammatory bowel disease: a nationwide population-based cohort study
Alimentary Pharmacology&Therapeutics, 2018-06,
국외
Byung Ha Chun, Mi-La Cho, Chul Woo Yang
Clinical significance of Th17 cells in kidney transplantation.
Korean Journal of Internal Medicine, 2018-05,
국외 (6)
, Park JS, Kim NR, Lim MA, Kim SM, Hwang SH, Jung KA, Choi J, Park SH, Cho ML.
Deficiency of IL-1 receptor antagonist suppresses IL-10-producing B cells in autoimmune arthritis in an IL-17/Th17-dependent manner To be published in: Immunology Letters
, 2018/07,
국외 (294)
, Lee SH, Lee HR, Kwon JY, Jung K, Kim SY, Cho KH, Choi J, Lee HH, Lee BI, Jue DM, Cho ML.
A20 ameliorates inflammatory bowel disease in mice via inhibiting NF-κB and STAT3 activation.
Immunology Letters, 2018/06,
국외
, Jhun J, Lee SH, Lee SK, Kim HY, Jung ES, Kim DG, Choi J, Bae SH, Yoon SK, Chung BH, Yang CW, Cho ML, Choi JY.
Serial Monitoring of Immune Markers Being Represented Treg/Th17 Ratio: Indicating Tolerance for Tapering Immunosuppression after Liver Transplantation
Front Immunol., 2018/03,
국외
, Kwon JE, Lee SY, Seo HB, Moon YM, Ryu JG, Jung KA, Jhun JY, Park JS, Hwang SS, Kim JM, Lee GR, Park SH, Cho ML.
YinYang1 deficiency ameliorates joint inflammation in a murine model of rheumatoid arthritis by modulating Th17 cell activation.
Immunology Letters, 2018/05,
국외 (73)
, Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, Lee HJ, Kim EK, Jhun JY, Cho ML, Min JK, Cho YY.
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
Cell Death & Disease, 2018/03/01,
국외
, Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
Fraxinellone Attenuates Rheumatoid Inflammation in Mice.
International journal of molecular sciences, 2018/03/13,
국외
, Park MJ, Lee SH, Kim EK, Lee EJ, Baek JA, Park SH, Kwok SK, Cho ML.
Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice
Scientific Reports, 2018/02/01,
국외
, Park JS, Choi J, Kwon JY, Jung KA, Yang CW, Park SH, Cho ML.
A Probiotic Complex, Rosavin, Zinc, and Prebiotics Ameliorate Intestinal Inflammation in an Acute Colitis Mouse Model
"Journal of Translational Medicine, 2018/02/21,
국외 (1)
, Kim EK, Lee SH, Lee SY, Kim JK, Jhun JY, Na HS, Kim SY, Choi JY, Yang CW, Park SH, Cho ML.
Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation.
Experimental & Molecular Medicine, 2018/01/26,
국외
, Lee SY, Lee SH, Jhun J, Seo HB, Jung KA, Yang CW, Park SH, Cho ML.
A Combination with Probiotic Complex, Zinc, and Coenzyme Q10 Attenuates Autoimmune Arthritis by Regulation of Th17/Treg Balance.e
Journal of Medicinal Food, 2018/01,
국외
, Kwon JY, Lee SH, Jhun J, Choi J, Jung K, Cho KH, Kim SJ, Yang CW, Park SH, Cho ML.
"The combination of probiotic complex, rosavin and zinc improves pain and cartilage destruction an in osteoarthritis rat model Short title: Probiotic complex, rosavin and zinc alleviates OA
Journal of Medicinal Food, 2018/04/01,
 
 
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