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ÀÛ¼ºÀÏ : 19-05-01 14:40
Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells
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±¹³»/±¹¿Ü ±¸ºÐ | : ±¹¿Ü |
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SCI/SCIE/ºñSCI ±¸ºÐ | : SCI |
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³í¹®Á¦¸ñ | : Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells |
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Á¦ 1ÀúÀÚ, ±³½ÅÀúÀÚ | : Jin-Sil Park, Mi-La Cho, Sung-Hwan Park |
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³ª¸ÓÁö ÀúÀÚ | : Sung-Min Kim, Sun-Hee Hwang, Si-Young Choi, Ji Ye Kwon, Seung-Ki Kwok, |
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ÇмúÁö¸í | : International Journal of Immunopathology and Pharmacology |
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Vol(No),ÆäÀÌÁö | : |
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¹ßÇà³â¿ùÀÏ | : 2018-06 |
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vÆÄÀÏ´Ù¿î·Îµå | : 2018-06 |
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Abstract Systemic lupus erythematosus (SLE; lupus) is a prototypical autoimmune disease characterized by circulating autoantibodies to nuclear antigens and immune complex deposition, resulting in damage to target organs. To investigate the effects of tacrolimus (TAC) on effector T cells and B cells, we examined its involvement in the development of effector T cells, germinal center (GC) B cells, and plasma cells in an in vitro system using wild-type (WT) and lupus-prone mice. The population of T helper (Th) 1, Th2, and Th17 cells interleukin (IL)-17-producing T (Th17) cells and the production of interferon-¥ã and interleukin-17A IL-17A were suppressed by TAC. TAC also reduced the population of regulatory T(Treg) cells; however, a combination treatment with the signal transducer and activator of transcript-xion 3 (STAT3) inhibitor STA-21 promoted the population of Treg cells. TAC also suppressed the populations of GC B cells and plasma cells synergistically with STA-21. These findings suggest that the application of TAC with a STAT3 signal inhibitor may provide benefits in SLE treatment.
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