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작성일 : 19-05-01 14:40
Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells
제 1저자, 교신저자: Jin-Sil Park, Mi-La Cho, Sung-Hwan Park
나머지 저자: Sung-Min Kim, Sun-Hee Hwang, Si-Young Choi, Ji Ye Kwon, Seung-Ki Kwok,
학술지명: International Journal of Immunopathology and Pharmacology 
Vol(No),페이지:
발행년월일: 2018-06
v파일다운로드: 2018-06
Abstract
Systemic lupus erythematosus (SLE; lupus) is a prototypical autoimmune disease characterized by circulating autoantibodies to nuclear antigens and immune complex deposition, resulting in damage to target organs. To investigate the effects of tacrolimus (TAC) on effector T cells and B cells, we examined its involvement in the development of effector T cells, germinal center (GC) B cells, and plasma cells in an in vitro system using wild-type (WT) and lupus-prone mice. The population of T helper (Th) 1, Th2, and Th17 cells interleukin (IL)-17-producing T (Th17) cells and the production of interferon-γ and interleukin-17A IL-17A were suppressed by TAC. TAC also reduced the population of regulatory T(Treg) cells; however, a combination treatment with the signal transducer and activator of transcript-xion 3 (STAT3) inhibitor STA-21 promoted the population of Treg cells. TAC also suppressed the populations of GC B cells and plasma cells synergistically with STA-21. These findings suggest that the application of TAC with a STAT3 signal inhibitor may provide benefits in SLE treatment.

 
 

 
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