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작성일 : 19-05-01 14:43
Clinical significance of CCR7+CD8+ T cells in kidney transplant recipients
국내/국외 구분: 국외
SCI/SCIE/비SCI 구분: SCI
논문제목: Clinical significance of CCR7+CD8+ T cells in kidney transplant recipients
제 1저자, 교신저자: Kyoung Woon Kim, Byung Ha Chung
나머지 저자: Kim Bo-Mi Kim, Kyoung Chan Doh, Mi-La Cho, Chul Woo Yang,
학술지명: Scientific Reprots
Vol(No),페이지:
발행년월일: 2018-06
v파일다운로드: 2018-06
The regulatory function of CCR7+CD8+ T cells against effector T-cells involved in T-cell mediated
rejection (TCMR) in kidney transplant recipients was investigated. In vitro experiments explored the
ability of CCR7+CD8+ T cells to suppress T-cell proliferation under T-cell activation conditions or during
coculture with human renal proximal tubular epithelial cells (HRPTEpiC). In an ex vivo experiment, the
proportion of CCR7+/CD8+, FOXP3+/CCR7+CD8+ T and effector T-cell subsets were compared between the normal biopsy control (NC, n = 17) and TCMR group (n = 17). The CCR7+CD8+ T cells significantly suppressed the proliferation of CD4+ T cells and significantly decreased the proportion of IFN-γ+ and IL-17+/CD4+ T cells and inflammatory cytokine levels (all p < 0.05). After coculturing with HRPTEpiC,
CCR7+CD8+ T cells also suppressed T-cell differentiation into IL-2+, IFN-γ+, and IL-17+/CD4+ T cells (all p < 0.05). The TCMR group had significantly fewer CCR7+/CD8+ and FOXP3+/CCR7+CD8+ T in comparison with the NC group, but the proportions of all three effector T-cell subsets were increased in the TCMR group (all p < 0.05). The proportion of CCR7+/CD8+ T was inversely correlated with those of effector T-cell subsets. The results indicate that CCR7+CD8+ T cells may regulate effector T-cells involved in TCMR in an in vitro and in an ex vivo transplant model.

 
 

 
Total 180
국외
Kyoung Woon Kim, Byung Ha Chung, Kim Bo-Mi Kim, Kyoung Chan Doh, Mi-La Cho, Chul Woo Yang,
Clinical significance of CCR7+CD8+ T cells in kidney transplant recipients
Scientific Reprots, 2018-06,
국외
Jin-Sil Park, Mi-La Cho, Sung-Hwan Park, Sung-Min Kim, Sun-Hee Hwang, Si-Young Choi, Ji Ye Kwon, Seung-Ki Kwok,
Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells
International Journal of Immunopathology and Pharmacology , 2018-06,
국외
Jung Min Bae, Han Hee Lee,Bo-In Lee,Kang-Moon Lee, Eun SH, Cho ML, Kim JS, Park JM, Cho YS, Lee IS, Kim SW, Choi H, Choi MG.
Incidence of psoriasiform diseases secondary to tumour necrosis factor antagonists in patients with inflammatory bowel disease: a nationwide population-based cohort study
Alimentary Pharmacology&Therapeutics, 2018-06,
국외
Byung Ha Chun, Mi-La Cho, Chul Woo Yang
Clinical significance of Th17 cells in kidney transplantation.
Korean Journal of Internal Medicine, 2018-05,
국외
, Park JS, Kim NR, Lim MA, Kim SM, Hwang SH, Jung KA, Choi J, Park SH, Cho ML.
Deficiency of IL-1 receptor antagonist suppresses IL-10-producing B cells in autoimmune arthritis in an IL-17/Th17-dependent manner To be published in: Immunology Letters
, 2018/07,
국외 (269)
, Lee SH, Lee HR, Kwon JY, Jung K, Kim SY, Cho KH, Choi J, Lee HH, Lee BI, Jue DM, Cho ML.
A20 ameliorates inflammatory bowel disease in mice via inhibiting NF-κB and STAT3 activation.
Immunology Letters, 2018/06,
국외
, Jhun J, Lee SH, Lee SK, Kim HY, Jung ES, Kim DG, Choi J, Bae SH, Yoon SK, Chung BH, Yang CW, Cho ML, Choi JY.
Serial Monitoring of Immune Markers Being Represented Treg/Th17 Ratio: Indicating Tolerance for Tapering Immunosuppression after Liver Transplantation
Front Immunol., 2018/03,
국외
, Kwon JE, Lee SY, Seo HB, Moon YM, Ryu JG, Jung KA, Jhun JY, Park JS, Hwang SS, Kim JM, Lee GR, Park SH, Cho ML.
YinYang1 deficiency ameliorates joint inflammation in a murine model of rheumatoid arthritis by modulating Th17 cell activation.
Immunology Letters, 2018/05,
국외 (63)
, Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, Lee HJ, Kim EK, Jhun JY, Cho ML, Min JK, Cho YY.
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
Cell Death & Disease, 2018/03/01,
국외
, Jung SM, Lee J, Baek SY, Lee J, Jang SG, Hong SM, Park JS, Cho ML, Park SH, Kwok SK.
Fraxinellone Attenuates Rheumatoid Inflammation in Mice.
International journal of molecular sciences, 2018/03/13,
국외
, Park MJ, Lee SH, Kim EK, Lee EJ, Baek JA, Park SH, Kwok SK, Cho ML.
Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice
Scientific Reports, 2018/02/01,
국외
, Park JS, Choi J, Kwon JY, Jung KA, Yang CW, Park SH, Cho ML.
A Probiotic Complex, Rosavin, Zinc, and Prebiotics Ameliorate Intestinal Inflammation in an Acute Colitis Mouse Model
"Journal of Translational Medicine, 2018/02/21,
국외 (1)
, Kim EK, Lee SH, Lee SY, Kim JK, Jhun JY, Na HS, Kim SY, Choi JY, Yang CW, Park SH, Cho ML.
Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation.
Experimental & Molecular Medicine, 2018/01/26,
국외
, Lee SY, Lee SH, Jhun J, Seo HB, Jung KA, Yang CW, Park SH, Cho ML.
A Combination with Probiotic Complex, Zinc, and Coenzyme Q10 Attenuates Autoimmune Arthritis by Regulation of Th17/Treg Balance.e
Journal of Medicinal Food, 2018/01,
국외
, Kwon JY, Lee SH, Jhun J, Choi J, Jung K, Cho KH, Kim SJ, Yang CW, Park SH, Cho ML.
"The combination of probiotic complex, rosavin and zinc improves pain and cartilage destruction an in osteoarthritis rat model Short title: Probiotic complex, rosavin and zinc alleviates OA
Journal of Medicinal Food, 2018/04/01,
 
 
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