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Keyword Pointed Keyword Related Keyword
Rheumatism gene Autoimmunity
T cell/Dentritic cell(DC) tolerance cytokines/ transcriptional factor
cell therapy regulation of inflammation Transgenic/Knockout(Tg/KO) animal
Purpose of Research

With the beginning of the new millennium, the World Health Organization has announced the next ten years as “Bone and Joint Decade” and organized the Global Arthritis Research Network which consists of USA , Europe and Asia . Such movement calls for an establishment of a representative rheumatology research center in Korea . We are planning to make up an first-class research group capable of developing innovative techniques in the cure of rheumatism through the integrated work of basic and clinical studies . Information gathered from this plan will contribute to improve the survival rate and life quality of patients suffering from rheumatic diseases. It will also reduce direct and indirect medical costs, and support the invention of new substances for the treatment of rheumatism.

Research Orientation

Rheumatic Diseases, including rheumatoid arthritis , osteoarthritis, and lupus, are autoimmune disease, affected by microbial infection, genetic factors, and environmental factors. To understand the disease etiology rheumatic disease and to suggest the therapeutic strategies, 5 th generalization are focusing that how the disease are occurred, which factors are engaged, and how those factors are cooperating each others, from molecular level to the small animal level. In molecular level, Jue, D.M. is focused on the regulation of NFkB especially by the serine protease inhibitor and Kim, H.Y. and Park, S.H. are trying to figure out how the differentiation factors for Th1, Th2, Treg and Th17 are regulated depending on external stimulus, cell cycles, and the status of methylation. In cellular level, Kim, H.Y. is focusing how the dendritic cell, T cells, and fibroblast-like synoviocytes are interacting to each others in directly and indirectly, and how these cells are accelerating the inflammation. Chung, D.H. is focusing the role of NKT cell in rheumatoid arthritis and the mechanism of disease acceleration by NKT cells. Kim, H.Y. Chung, D.H. are using small animal model to evaluating the regulatory function of dendritic cells, T cells, and NKT cells. Kim, H.Y. and Lee, S.H. are also interested in the mechanism of bone destruction, especially how the arthritic environmental is driving the differentiation of osteoclasts. 5 th generalization are also testing some therapeutics and trying to find method to regulating the autoimmunity. 8 th generalization are focusing on how the oral tolerance are maintained and how tolerize the autoimmunity. Kang, C.Y. is focusing on which region, type of cells are engaged on oral tolerance and is try to find novel mechanism for oral tolerance. Kim, H.Y. is testing the effects of antigen-amounts in oral tolerance and the role of IDO-expressing DC in oral tolerance. Min, J.K. is studying the role of B cells on immune tolerance . Park, S.H. is using the soluble MHC, which is specific to auto-antigen, to regulate or induce immune tolerance. Interestingly, Cho, S.G. is studying the recovery of immune tolerance by mixed chimerism. He is studying the mechanism for mixed chimerism and seeking the condition for stabilizing mixed chimerism. All these studies are under the beautiful collaboration and we hope that new stratagem for the treatment of rheumatic disease will be come out.

Expected Effects

We, as an integrated study group of a foremost rheumatology researchers, hope to overcome the limits in the conventional methods in individual research, and to develop novel approaches for the treatment of the disease. We also aim at defining the still-unknown etiology of rheumatism and developing new treatment strategies for other autoimmune diseases such as multiple sclerosis, diabetes mellitus, and uveitis. Our plan to develop new gene transfer vectors and vaccines with improved efficacy, together with the future employment of Tg/KO animal models and cell therapy, will contribute greatly to the invention of novel medicine with international competitiveness. Researches in this so-called “post-genome era” surely requires advances in specialized fields of biotechnology through the congregation of basic and clinical sciences. Cultivation of such technique in Korea will reduce our dependency on foreign medical trade. Last but not the least, this project will bring hopes not only to patients who can have their normal lives back, but also to the society by letting workers return to their work places in a healthy state.






류마티스연구센터 서울시 서초구 반포동 505번지 가톨릭대학교 의과학연구원 5017호
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